Journal Title: Shandong Journal of Traditional Chinese Medicine ISSN：0257-358X CN：37-1164/R Sponsors: Shandong Association of Traditional Chinese Medicine; Shandong University of Traditional Chinese Medicine
Through the exploration of theoretical basis of tonifying kidney and dredging Fu-organ method for treatment of vascular dementia and analysis of its clinical application and related animal experiment results,it is pointed out that deficiency of kidney essence is the main pathogenesis of vascular dementia and Qi obstruction of Fu-organ is the symptomatic element,so rheum officinale,polygonum multiflorum,radix rehmanniae,rhizoma alismatis,etc. are commonly used drugs. Based on the theory of dredging in order to tonifying,the clinical application of tonifying kidney and dredging Fu-organ method according to syndrome differentiation in vascular dementia is a clear idea,but its flexible application in clinic still need to be explored.
With the development of social economy,the clinical manifestation of mast patients with type 2diabetes mellitus(T2DM) is obesity instead of excessive drink,polyuria,excessive food and weight loss,so it is biased to treat T2DM only from the pathogenesis of "internal heat caused by Yin deficiency" or "Spleen failing to transporting essence and internal excess of phlegm and dampness". The theory that dampness and dryness are isomorphic and can make the same disease is closely related to T2DM,because the accumulation of dampness makes the fluid fail to be transported and then generates dryness,similarly,the accumulation of dryness makes the water fail to flow and then generates dampness,which means dampness and dryness have important position in the pathogenesis of T2DM. So treating T2DM by simultaneous elimination of dryness and dampness can achieve good clinical curative effect. The theory is the embodiment of the holism concept and the idea of "treating disease before its onset" of traditional Chinese medicine and it can broaden our mind in clinical treatment.
The theory that the lung and the large intestine form an external-internal relationship has shown its superiority in long-term treatment based on syndrome differentiation. At present,most of the diseases involving the lung and the large intestine were treated by purgation and dispersing Qi of the lung. The research on the theory is going deeper and the internal relationship between the lung and the large intestine is began to be studied from the microscopic level such as histology,embryology,immunology and neuro-endocrine system,etc.,which gave the interpretation and verification of the possible mechanisms of the relationship between the lung and the large intestine to a certain extent. But seeing from the complexity of mutual relations between Zang and Fu organs established by the meridians,only characterizing the relationship between the lung and the large intestine from one level or the change of one index is not comprehensive.Therefore,based on transcriptomics and bioinformatics,the common differentially expressed genes in the tissue of the lung and the large intestine can be screened from huge amounts of transcription information in disease transmission,the signal pathways which have the same changes of differences can be found and the transmission way in the pathological changes of "lung disease involving the large intestine" and "large intestine disease involving the lung" can be explored. All the above can provide new thoughts and methods for revealing the connotation of the theory.
In clinic of Traditional Chinese Medicine(TCM),it is found diseases and syndromes of Zang-Fu organs have different nature of cold or heat,which can not be explained clearly. Based on the theory of five elements and six nature factors and the frame of manifestation,root cause and medial Qi,the differences of Yin and Yang nature of Zang-Fu organs were discussed and the differences of clinical diseases and syndromes of Zang-Fu organs were explained. According to the incidence rules observed in the clinic and following the principle of Yunqi as the root and three Yin and three Yang as the manifestation,the relationship between manifestation and medial Qi can be showed by one Yin to one Yang,two Yin to two Yang,three Yin to three Yang,then the relationship between manifestation,root cause and medial Qi and clinical diseases and syndromes of Zang-Fu organs can be better explained.
Based on years of clinical experience,the Chinese medicine great master ZHOU Zhongying has created a systematic pathogenesis theory of "blood stasis and heat". Under the guidance of Professor Zhou's theory,through analysis of the relating literature,and combined with the clinical practice,this paper discusses the pathogenesis,clinical manifestations,thoughts of differentiation and medication characteristics of blood stasis and heat in epididymitis and orchitis,with a case for illustration. It enriches the theory of "blood stasis and heat" and provides new insights for the treatment of epididymitis and orchitis based on syndrome differentiation.
Colorectal cancer is one of the most common malignant tumor of digestive tract. Based on the summary of the understandings of cancer of generations of physicians,the etiology,pathogenesis and syndrome types of colorectal cancer are analyzed. In treatment of the disease,strengthening the body resistance to eliminate pathogenic evil and combining tonification and purgation should be the main methods. Methods for strengthening body resistance includes supplementing the spleen,tonifying the kidney,nourishing Yin. Methods for eliminating the pathogenic evil includes promoting blood circulation to resolving blood stasis,resolving phlegm and removing dampness,clearing heat and removing poison. This paper aims at guiding the clinical treatment.
The method of ironing with medicine originates from treatment of diseases such as joint pain by hot stone roasted on fire in ancient times. Inherited and developed by generations of doctors,the method of ironing with medicine has formed a variety of categories and each has distinct characteristics. In The Inner Canon of Huangdi,there are lots of records about the method of ironing with medicine and there is a special chapter to discuss it. By consulting the relevant literature,this paper summarizes the original records,composition of prescriptions,production and usage,indications and applicable people of the method of ironing with medicine in The Inner Canon of Huangdi,so as to help to understand the procedure and treatment characteristics of the method of ironing with medicine and provide better services for modern clinical treatment.
Objective:To observe the clinical effect of Longfu formula on the treatment of chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS) which were classified by the urinary,psychosocial,organ-specific,infection,neurologic/systemic,tenderness(UPOINT) system. Methods:A total of 100 patients diagnosed as CP/CPPS were enrolled in this study. All patients were classified by the UPOINT system and underwent a12-week therapy of Longfu formula. The national institutes of health-chronic prostatitis symptom index(NIH-CPSI) and adverse events of the patients were evaluated before treatment,6 weeks after treatment and12 weeks after treatment respectively. The correlation between UPOINT factors and the decrease of NIH-CPSI after treatment by Longfu formula was analyzed. According to the assessment criteria,the clinical result was either effective or ineffective. Results:The Longfu formula was effective on 75 patients and ineffective on 20 cases. The total effective rate was 78.95%(75/95). The factor of U,O,T were correlated with the decrease of NIH-CPSI(P<0.01). Conclusion:Longfu formula is safe and effective on CP/CPPS of which the U,O,T factor was positive.
Objective:To carry out a clinical study on the secondary prevention of cerebral stroke with acupuncture intervention in hypertension on the basis of "preventive treatment of disease" theory and observe the blood pressure control rate and long-term prognosis of the patients. Methods:A total of 60 patients with hypertension after stroke were randomly divided into treatment group and control group,with 30 cases in each group. The treatment group was treated by Xingnao Kaiqiao(XNKQ) acupuncture method and acupuncture on antihypertensive points,while the control group was only treated by XNKQ acupuncture method. All the patients underwent the 24-hour ambulatory blood pressure monitoring within 48 hours of admission. The Barthel index and national institute of health stroke scale(NIHSS) scores of the patients were evaluated at admission and the third followed up month. Results : 1 For the comparison of the antihypertensive effects within each group before and after treatment and between the two groups,the differences were statistically significant(P<0.05). 2After 3 months,the Barthel index and NIHSS scores of the two groups were better than those before treatment,with statistical significance(P<0.05). 3For the comparison of the usage of antihypertensive drugs after 3 months,the methods of both the two groups can help some patients reduce or even drop the drugs,and the effect of the treatment group was superior to that of the control group(P<0.05). It showed that the methods of both the two groups can lower blood pressure,but the antihypertensive effect of the treatment group was superior to that of the control group. Conclusion:The XNKQ acupuncture method and acupuncture on antihypertensive points can significantly lower the blood pressure and improve the neural function of the patients.
According to the anatomical features and pathological manifestations of the facial nerve in the geniculate ganglion,inheriting traditional Chinese medicine and combining with modern medicine,the theory of the disease was innovated and developed by Professor LIU Yutan. He divides peripheral facial paralysis into four types and takes acupuncture,bloodletting,moxibustion and Chinese medicine to treat the disease according to its type and stage. With reasonable compatibility,his prescription can improve the cure rate and shorten the course of treatment of peripheral facial paralysis. It is the over 50-year clinical experience of teacher LIU,as well as the innovation and development based on traditional Chinese and modern medicine.
Objective:To observe the effect of lung-regulating and intestine-benefiting acupuncture method on improvement of elderly patients' bowel function after radical resection for colon cancer. Methods:A total of60 elderly patients with colon cancer undergoing selective operation were randomly divided into acupuncture group and blank control group. After operation,under the same basic treatment,the acupuncture group was treated by lung-regulating and intestine-benefiting acupuncture method for 2 weeks and the blank control group was not treated by acupuncture. The following indicators of the two groups were observed:the first time when patients took semifluid food and defecated yellow liquid stool,the first exhaust or defecation time,the frequency of defecation within two weeks after operation,daily volume of defecation,drainage volume of gastrointestinal decompression,the L/M value of urine and D-lactic acid value of blood on the day when patients drank water and ten days after patients drank water. Results:Two weeks after treatment,compared with the blank control group,the first exhaust time of the acupuncture group was obviously shortened(P<0.05),the daily average volume of defecation of the acupuncture group was obviously increased(P <0.05), the drainage volume of gastrointestinal decompression of the acupuncture group was decreased significantly(P<0.05),but there were no significant differences in the rest indicators. Conclusion:The lung-regulating and intestine-benefiting acupuncture method can improve the elderly patients' bowel function after radical resection for colon cancer. More specifically,it can promote intestinal peristalsis,shorten the first exhaust time,increase the daily average volume of defecation,reduce the drainage volume of gastrointestinal decompression,but it had no obvious effect on improving intestinal mucosal permeability.
Objective:To observe the clinical efficacy of Guben Yangzang decoction on malnutrition during a cute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods:A total of 160 patients with malnutrition during AECOPD were randomly divided into two groups. The 80 patients in the control group were treated by parenteral nutrition therapy,while the other 80 patients in the treatment group were treated by daily diet combined with Guben Yangzang decoction. Clinical indicators such as hemoglobin,albumin and blood gas analysis,socioeconomic indicators such as hospital stays,duration of mechanical ventilation and cost of nutrition support,as well as security indicators such as liver and kidney function were observed. Results:The prealbumin,transferrin,blood gas analysis and other indicators of the two groups were improved com pared with those before treatment(P<0.05) and the improvements of the treatment group was better than those of the control group(P<0.05). The hospital stays and duration of mechanical ventilation of the treatment group was shorter than those of the control group(P<0.05) and the cost of nutrition support of the treatment group was less than those of the control group(P<0.05). Conclusion:Guben Yangzang decoction can improve the nutritional status and respiratory function of patients with AECOPD,shorten hospital stays and duration of mechanical ventilation and reduce the cost of nutrition support.
Objective:To observe the effect of emotional homeopathic psychotherapy on depression and life quality of patients with ischemic cerebral stroke. Methods:A total of 68 patients with depression after ischemic cerebral stroke were randomly divided into intervention group and control group,with 34 cases in each group. The intervention group was treated with emotional homeopathic psychotherapy on the basis of conventional treatment. The effect was evaluated by Hamilton depression(HAMD) scale and 36-item short-form(SF-36) 3 weeks before and after treatment. Results:After treated by emotional homeopathic psychotherapy,the HAMD score of the intervention group(15.46±2.78) was obviously lower than that of the control group(19.70±2.99) and the SF-36 score of the intervention group was significantly higher than that of the control group. The differences were statistically significant(P <0.05). Conclusion :The emotional homeopathic psychotherapy can significantly reduce depression and improve the life quality of the patients.
Objective:To explore the clinical curative effect of Feibi decoction combined with azithromycin on idiopathic pulmonary fibrosis. Methods:A total of 60 patients who were diagnosed as idiopathic pulmonary fibrosis were randomly divided into Feibi decoction group,azithromycin group and combination group,with 20 cases in each group. All the three groups were given conventional treatment(low flow oxygen+relieving cough and reducing sputum+anti-infection+hormone therapy). On the basis of the conventional treatment,Feibi decoction was added to the Feibi decoction group,azithromycin was added to the azithromycin group and Feibi decoction and azithromycin were added to the combination group. All the medicines were taken continuously for 15 days. Results:After treatment,the clinical manifestations and lung function of all the three groups were improved in different degree. In the combination group,symptoms of the patients were improved more obviously,the vital capacity(VC) and arterial oxygen partial pressure(PaO_2) were improved more prominent,and the effective rate was higher than that of the other two groups. There were no obvious adverse reactions in the three groups during the process of treatment. Conclusion:Feibi decoction combined with azithromycin has better effect on the treatment of idiopathic pulmonary fibrosis.
Objective:Cooperating with the standardization of diagnosis and treatment of traditional Chinese medicine(TCM) carried out by the state administration of TCM,to evaluate the applicability of the Draft of Diagnosis and Treatment Guideline of TCM for Children Allergic Purpura in Jinan Area retrospectively.Methods:Children with allergic purpura who visited the affiliated hospital of shandong university of TCM from April 2012 to April 2014 were randomly selected for the study. Their clinical data was filled in the Case Questionnaire for Application Evaluation of Diagnosis and Treatment Guideline of TCM. And then the clinical data was statistically analyzed. Results : 1 The coincidence rate of the name of children allergic purpura in diagnosis was 100%,in which the coincidence rate of TCM syndrome of allergic purpura was90.91% and that of TCM syndrome of purpura nephritis was 39.48%. 2The coincidence rate of TCM therapeutic principles and methods of allergic purpura was 81.82% and that of the prescriptions and medicines was 61.04%. The coincidence rate of TCM therapeutic principles and methods of purpura nephritis was34.21% and that of the prescriptions and medicines was 39.47%. 3The effective and curative rate of TCM diagnosis and treatment for children allergic purpura was 86.96%. For security evaluation,"terrific" accounted for 72.17% and "better" accounted for 27.83%. For economic evaluation, "terrific" accounted for 69.56%,"better " accounted for 21.74% and "good " accounted for 8.70%. Conclusion :The guideline was generally suitable for clinical application and can be used as the standard for treatment of this disease,but it needs further improvement. Suggestions for syndrome differentiation:syndrome of blood stasis in the collateral should be added to the allergic purpura syndrome differentiation. Syndrome of dampness-heat with blood stasis,blood stasis in the collateral and deficiency of spleen and kidney Yang should be added to purpura nephritis syndrome differentiation. Contents about nursing and prevention should be added.
Objective:To observe the effect of eight-section brocade combined with balance training on balance fuction disorder after cerebral stroke. Methods:A total of 62 cerebral stroke patients with balance fuction disorder were divided into observation group(n=31) and control group(n=31) according to the random number table. All patients of the two groups were given conventional medical therapy. On basis of the medical therapy,the control group received balance training and the observation group received eight-section brocade combined with balance training. The curative effect was evaluated by Fugl-Meyer assessment of lower extremity(FMA-L) and Berg balance scale(BBS) after 8 courses of treatment. Results :After treatment,the FMA-L and BBS scores of the two groups were all higher than those before treatment(P<0.05) and the recovery of the observation group was superior to the control group(P<0.05). Conclusion:Eight-section brocade combined with balance training can improve the balance function of cerebral stroke patients.
Objective:To observe the effect of Shengji Xiangpi paste on wound healing after operation for anal fissure. Methods:A total of 100 cases who met the diagnostic standards were randomly divided into treatment group and control group,with 50 cases in each group. After operation,Vaseline oil gauze was used on the wound in the control group,Shengji Xiangpi paste was used on the wound in the treatment group.The wound area,granulation tissue,epithelial growth,wound secretions and average healing time of the two groups were observed and compared respectively on the 3th,7th,11 th,14th day after the operation. Results:The differences of reduction of wound area,growth of epithelial cells and granulation tissue and quality and quantity of pus secretion between the two groups were statistically significant(P<0.05). The average wound healing time of the treatment group was(18.21±2.60) days and that of the the control group was(22.08±3.74) days. The difference was statistically significant(P<0.05). Conclusion:Shengji Xiangpi paste can promote the secretion of pus,the growth of flesh and the wound repair,shorten the wound healing time,which is beneficial to the healing of wounds.
Professor CAO Lingxian's experience in treating gynecological diseases with characteristic couplet medicinals is summarized as follows:madder root combined with cuttlefish bone for treatment of hypomenorrhea,delayed menstrual cycle and amenorrhea,kudzuvine root combined with common anemarrhena rhizome for treatment of premature ovarian failure and diminished ovarian reserve,spine date seed combined with poria with hostwood for treatment of insomnia caused by deficiency of liver blood,pinellia combined with north husked sorghum for treatment of insomnia accompanied by symptoms like stomach disharmony and inhibited defecation,wolfberry bark combined with white mulberry root-bark and snakegourd fruit combined with dendrobium respectively for treatment of polycystic ovary syndrome patients with high androgen and insulin resistance,grassleaf sweetflag rhizome combined with polygala root for treatment of hypogonadotropic amenorrhea. To illustrate the experience,some examples are given.
To summarize Professor XUE Yitao's experience in treating chest impediment by Bupleurum Liver-soothing and Mind-Tranquilizing decoction. Professor XUE treats pain in chest and back from the angle of chest impediment in traditional Chinese medicine and thinks the pathogenesis includes Qi stagnation,blood stasis,accumulation of coldness and phlegm. According to the principle of resolving the current problems before eliminating the root causes,the first step in treatment is regulating Qi,promoting blood circulation,unblocking meridians and the second step is supplementing Qi,nourishing Yin and warming Yang. In clinical treatment,Bupleurum Liver-soothing and Mind-Tranquilizing decoction has satisfactory effect.
Zisou,also known as gestatinal cough,is the cough and prolonged cough which can not be cured for a long time during pregnancy. Due to the special maternal physiological characteristics(Yin and blood deficiency,hyperactivity of Yang Qi) during pregnancy,most of the gestational cough in clinic belongs to Yin deficiency and lung dryness syndrome. Chief physician ZHANG Jing is good at treating gestational cough.This paper summarizes ZHANG Jing's rich experience in etiology,pathogenesis,syndrome differentiation and treatment of gestational cough and lists a case for support.
Professor LI Yan thinks insomnia is caused by emotion,diet,tiredness,weakness,fright and other causes which can result in malnutrition of heart spirit,heat harassing the heart spirit,spirit failing to keep to its adobe. In a word,insomnia is associated with heart,liver,spleen,kidney and deficiency of Qi and blood.Syndromes commonly seen in clinic include non-interaction between the heart and kidney,deficiency of brain and kidney,hyperactivity of heart Yang,deficiency of Yin,deficiency of Yang,stomach Qi failing to bear downward,liver meridian injury,gallbladder stagnation and blood stasis obstructing the collaterals. The paper lists a typical case of insomnia treated by Professor LI Yan,so as to analyze his thoughts on prescriptions,mechanism,syndrome differentiation and treatment of insomnia.
Objective:To observe the effects of Xuanfu Daizhe decoction and its disassembled prescriptions on esophageal mitochondrial membrane potential(MMP) of model rats with reflux esophagitis(RE) and analyze the mechanism behind the effects from the perspective of energy metabolism. Methods:A total of 150 healthy male Wistar rats were randomly divided into 10 groups:model control group,normal control group,Xuanfu Daizhe decoction group,bitter descending group,western medicine group,sweet ascending group,ascending and descending group,complete prescription excluding bitter descending group,complete prescription excluding sweet ascending group and complete prescription excluding descending and ascending group. After the model rats of acid and alkali mixed RE were established,the rats were normally fed for 7 days. From the 8th day,rats in Xuanfu Daizhe decoction group and disassembled prescriptions group were given corresponding decoction by gavage,while the rats in the western medicine group were given mosapride + lansoprazole and the rats in the control groups(normal group+model group) were given saline by gavage. After killing the rats,the morphological changes of the lower esophageal mucosal were observed and the expression of MMP of esophageal tissue was measured by rhodamine 123. Results :1The weights of Xuanfu Daizhe decoction group,sweet ascending group,complete prescription excluding bitter descending group,ascending and descending group and western medicine group was obviously different from those of the model control group(P<0.05). 2The pathological scores of esophageal mucosa of Xuanfu Daizhe decoction group,sweet ascending group,complete prescription excluding bitter descending group,ascending and descending group and western medicine group were obviously different from those of the model control group(P<0.05). 3The MMP of esophageal tissue of Xuanfu Daizhe decoction group,sweet ascending group,complete prescription excluding bitter descending group,ascending and descend ing group and western medicine group was obviously higher than that of the model control group(P<0.05). 4There were no significant differences of all the observational indexes among bitter descending group,complete prescription excluding sweet ascending group,complete prescription excluding descending and ascending group. Conclusion:Xuanfu Daizhe decoction is able to stabilize the MMP of esophageal tissue of RE rats,which may be one of the mechanisms for improving the esophageal sphincter relaxation of RE rats.
Objective:To establish the fingerprint of lipid-soluble components of genuine salvia miltiorrhiza bunge in Shandong and to perform simultaneous determination of three components in it. Methods:The analysis were performed on Sciences-Inert Sustain C18 column,with acetonitrile-0.02% phosphoric acid solution as the eluent. The flow rate was 1.0 m L/min and the temperature was 30 ℃. Results:Twenty common peaks were identified form the fingerprints of 10 batches of salvia miltiorrhiza bunge and the similarities were not less than 0.940. The linear ranges of tanshinoneⅠ,tanshinoneⅡA and cryptotanshinone were 0.11~2.2 μg,0.052~1.04 μg and 0.043~0.086. Conclusion:The established method is simple and the result was accurate.They can provide reference for quality control of salvia miltiorrhiza bunge.
The incidence of mycoplasma pneumonia(MPP) is increasing year by year and the disease is often protracted,refractory and recurrent. At present,the treatment of MPP is a comprehensive therapy based on macrolide antibiotics,in which traditional Chinese medicine is an important component. The method of freeing the collateral vessels is based on the theory of collateral diseases. A lot of medicines and prescriptions for freeing the collateral vessels are of great importance in improving the clinical curative effect,shortening the course of disease,preventing the repeated infection and so on. The application of freeing the collateral vessels in the treatment of children with MPP is summarized. There are 30 references in this paper.
Ascites is one of the most common complications in patients with cirrhosis. Its continuity and repeatability is a big problem in the process of clinical treatment. In clinical treatment,different doctors advocate different ideas. The author retrieved the experience of famous Chinese medicine experts in treating ascites due to cirrhosis which was recorded in Wanfang database and chinese national knowledge infrastructure(CNKI) since 2006,with ascites due to cirrhosis and experience as the keywords. The experience is summarized from the following aspects:the understanding of etiology and pathogenesis,clinical treatment and medication characteristics. There are 34 references in this paper.
